inflammation
Inflammation: Basic Control Complex
This complex centers on two named members—Omega-3 and Curcumin—rather than a single ingredient.
Overview
Inflammation: Basic Control Complex brings together Omega-3 and Curcumin for complementary nutritional and polyphenol-based support. The formulation is intended to address several connected goals at once, including lipid metabolism, metabolic health, inflammatory balance, and concerns associated with chronic inflammation. Its design also reflects overlapping potential relevance to weight management, insulin sensitivity, pain, and antioxidant protection rather than focusing on a single outcome.
The members share a broad, multi-system orientation: Omega-3 and Curcumin are each presented in relation to cardiometabolic and inflammation-related goals, with the combination chosen to provide complementary support. This may make the bundle relevant to someone considering nutritional support across more than one of these areas, rather than a narrowly targeted product.
The evidence displayed for the listed outcomes belongs to the individual members, not to the bundle as a tested unit. The combination itself is not clinically established as a unit, so the shared rationale should be read as a formulation choice based on overlapping roles, not as proof that taking them together produces a combined effect. Individual circumstances, including the specific goal being considered, remain important when interpreting the information.
What's inside
Core
420 mg · Omega-3 Triglyceride (rTG)
First half of the day · With Fat
Omega-3 serves as a primary member, providing foundational anti-inflammatory action through EPA and DHA, which serve as precursors to specialized pro-resolving mediators (SPMs) that actively resolve inflammation. The listed amount is 420 mg.
CurcuminSupporting
400 mg · Longvida Solid Lipid Curcumin Particle
First half of the day · With Fat
Curcumin serves as a supporting member, helping enhance antioxidant capacity and support metabolic function, particularly insulin sensitivity and glucose regulation. The listed amount is 400 mg.
How to take it
| # | Ingredient | Form | Dose | When |
|---|---|---|---|---|
| 1 | Omega-3 | Omega-3 Triglyceride (rTG) | 420 mg | First half of the day · With Fat |
| 2 | Curcumin | Longvida Solid Lipid Curcumin Particle | 400 mg | First half of the day · With Fat |
- Expected onset
- 4–12 weeks
How it works
This formulation pairs Omega-3 with Curcumin to address complementary aspects of inflammatory and metabolic balance. Omega-3 provides the foundational anti-inflammatory role through EPA and DHA, which serve as precursors to specialized pro-resolving mediators that actively resolve inflammation. This gives the formulation a pathway focused on the regulation and resolution of inflammatory processes.
Curcumin contributes a different emphasis as a polyphenol that enhances antioxidant capacity and supports metabolic function, particularly insulin sensitivity and glucose regulation. Its role helps cover metabolic and oxidative aspects that are not the primary focus of Omega-3 alone, while also complementing Omega-3’s relevance to lipid metabolism and inflammatory balance.
The ingredients overlap around chronic inflammation-related goals, but they are not interchangeable: Omega-3 supplies the core lipid-based anti-inflammatory pathway, while Curcumin broadens the formulation toward antioxidant and metabolic support. The grouping is therefore a formulation choice based on complementary roles and shared relevance to inflammatory balance, not evidence that the combination itself has been clinically established as a unit.
Omega-3 and Curcumin are combined here on the basis of a shared pharmacologic effect: both inhibit platelet aggregation. This creates a plausible additive blood-thinning effect when used together, rather than two entirely separate actions.
The interaction is presented as a caution, not as evidence of a measured additive benefit. The available information supports the pharmacologic rationale for increased bruising and bleeding risk, but does not establish how large the combined effect is or whether it occurs in everyone.
This consideration is especially relevant around surgery and for people with bleeding disorders. In those settings, the combination may warrant particular caution because the potential effects overlap. No internal conflicts are identified beyond this bleeding-related concern.
Effects
55 listedStart here
Highest probability, strongest evidence
- →Triglyceride Level ReductionCertaintyHighSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
Medium probability(14)
- →Insulin Sensitivity ImprovementCertaintyMediumSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
- →Mood ImprovementCertaintyMediumSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
- →Muscle Recovery AccelerationCertaintyMediumSourceRCT
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Antioxidant Protection EnhancementCertaintyMediumSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
- →HDL Cholesterol IncreaseCertaintyMediumSourceRCT
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Muscle Mass IncreaseCertaintyMediumSourceRCT
This outcome comes from Omega-3 alone, not from testing the combination.
- →Anxiety ReductionCertaintyMediumSourceRCT
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Cholesterol Level ReductionCertaintyMediumSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
- →Chronic Pain ReductionCertaintyMediumSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
- →Blood Pressure SupportCertaintyMediumSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
- →Immune System SupportCertaintyMediumSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
- →Liver Health SupportCertaintyMediumSourceRCT
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Weight Management SupportCertaintyMediumSourceRCT
This is a design goal attributed to Omega-3 and Curcumin, with both members independently contributing. The combination itself has not been tested for this outcome.
- →Physical Strength IncreaseCertaintyMediumSourceClinical
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
Low probability(40)
- →Analgesic EffectCertaintyLowSourceRCT
This outcome comes from Curcumin alone, not from testing the combination.
- →Urinary Flow ImprovementCertaintyLowSourceRCT
This outcome comes from Curcumin alone, not from testing the combination.
- →Inflammation ReductionCertaintyLowSourceRCT
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Blood Glucose Level SupportCertaintyLowSourceRCT
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Antidepressant EffectCertaintyLowSourceClinical
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Joint Health ImprovementCertaintyLowSourceClinical
This outcome comes from Curcumin alone, not from testing the combination.
- →Learning Speed ImprovementCertaintyLowSourceClinical
This outcome comes from Omega-3 alone, not from testing the combination.
- →Workout Efficiency IncreaseCertaintyLowSourceClinical
This outcome comes from Omega-3 alone, not from testing the combination.
- →Muscle Soreness Reduction (DOMS)CertaintyLowSourceClinical
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Female Hormonal Balance SupportCertaintyLowSourceClinical
This outcome comes from Curcumin alone, not from testing the combination.
- →Migraine ReliefCertaintyLowSourceClinical
This outcome comes from Omega-3 alone, not from testing the combination.
- →Oral Health SupportCertaintyLowSourceClinical
This outcome comes from Curcumin alone, not from testing the combination.
- →Pregnancy Outcome SupportCertaintyLowSourceClinical
This outcome comes from Omega-3 alone, not from testing the combination.
- →Neuroprotective EffectCertaintyLowSourceReview
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Blood Flow ImprovementCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Fertility ImprovementCertaintyLowSourceReview
This outcome comes from Curcumin alone, not from testing the combination.
- →Grip Strength ImprovementCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Memory ImprovementCertaintyLowSourceReview
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Sleep Quality ImprovementCertaintyLowSourceReview
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Spatial Reasoning ImprovementCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Blood Oxygen Saturation ImprovementCertaintyLowSourceReview
This outcome comes from Curcumin alone, not from testing the combination.
- →Verbal Fluency ImprovementCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Working Memory ImprovementCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Physical Endurance IncreaseCertaintyLowSourceReview
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Reaction Speed IncreaseCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Testosterone Level IncreaseCertaintyLowSourceReview
This outcome comes from Curcumin alone, not from testing the combination.
- →Acne ReductionCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Fatty Liver PreventionCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Kidney Health SupportCertaintyLowSourceReview
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Longevity and Anti-Aging SupportCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Methylation SupportCertaintyLowSourceReview
This outcome comes from Curcumin alone, not from testing the combination.
- →Muscle PreservationCertaintyLowSourceReview
This outcome comes from Omega-3 alone, not from testing the combination.
- →Eye and Vision Health SupportCertaintyLowSourceReference knowledge
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Muscle RelaxationCertaintyLowSourceAnecdotal
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Alertness IncreaseCertaintyLowSourceAnecdotal
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Concentration ImprovementCertaintyLowSourceAnecdotal
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Physical Energy IncreaseCertaintyLowSourceAnecdotal
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Brain Fog ReductionCertaintyLowSourceAnecdotal
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Fatigue ReductionCertaintyLowSourceAnecdotal
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
- →Sexual Function and Libido ImprovementCertaintyLowSourceTheoretical
This outcome is attributed to Omega-3 and Curcumin, with both members independently contributing; it is not a finding from testing the combination.
Conditions it's used for
Complaints and diagnoses people take it for9 listedThe best we have, but the evidence is still weak
- →Chronic InflammationSourceScientific
This outcome is attributed to Omega-3 and Curcumin, with both members contributing independent evidence relevant to inflammatory balance. It reflects indirect relevance to the combination rather than findings from the exact combination.
- →DepressionSourceScientific
Both Omega-3 and Curcumin contribute to this row through roles related to neuroinflammation reduction and neurotransmitter modulation. The rationale supports an adjunctive role, not a proven effect of the combination.
- →Diabetes (General)SourceScientific
Omega-3 and Curcumin contribute to this row through support for insulin sensitivity and glucose regulation. This reflects convergence between the two members, without establishing a combination-level effect.
- →DyslipidemiaSourceScientific
Omega-3 is the main contributor through triglyceride-lowering and HDL-raising effects, with Curcumin providing supporting lipid modulation. Both members contribute independently; this does not show that their effects add together.
- →Hypertriglyceridemia (High Triglycerides)SourceScientific
Omega-3 is the principal contributor to this outcome, while Curcumin provides secondary metabolic support. Both members contribute, but their individual roles should not be interpreted as a tested combined effect.
- →Inflammatory PainSourceScientific
This row comes from both Omega-3 and Curcumin, which have independent relevance to pain and inflammatory symptoms. Their role is considered adjunctive rather than primary therapy.
- →Insulin ResistanceSourceScientific
Both Omega-3 and Curcumin contribute through independent actions related to insulin sensitivity, inflammation, and antioxidant activity. The rationale reflects convergence from two members rather than a tested effect of the combination.
Unrated(2)
- →Metabolic SyndromeSourceScientific
Omega-3 and Curcumin contribute through several associated features: triglycerides, insulin sensitivity, weight management, and blood pressure. This is a multi-feature rationale rather than a combination-level result.
- →Chronic PainSourceTheoretical
This row is attributed to Omega-3 and Curcumin through a rationale involving reduced inflammatory mediators and possible relief of pain in conditions such as arthritis or musculoskeletal inflammation. The proposed role is adjunctive.
Side effects
50 listedHighest probability
- →LDL Cholesterol IncreaseCertaintyMediumSourceRCT
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →ConstipationCertaintyMediumSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →DiarrheaCertaintyMediumSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →DizzinessCertaintyMediumSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →HeadacheCertaintyMediumSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →Heartburn / Acid RefluxCertaintyMediumSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →NauseaCertaintyMediumSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
Medium probability(3)
- →Taste DisordersCertaintyMediumSourceClinical
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Bruising (Ecchymosis)CertaintyMediumSourceReference knowledge
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →Drug Concentration IncreaseCertaintyMediumSourceReference knowledge
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
Low probability(32)
- →Allergic ReactionCertaintyLowSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →BloatingCertaintyLowSourceRCT
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Blood ThinningCertaintyLowSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →DrowsinessCertaintyLowSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →Fluid Retention (Edema)CertaintyLowSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →Gastric IrritationCertaintyLowSourceRCT
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Heart Rhythm DisturbanceCertaintyLowSourceRCT
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Hot FlashesCertaintyLowSourceRCT
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Insulin Resistance IncreaseCertaintyLowSourceRCT
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →RBC/Hemoglobin DecreaseCertaintyLowSourceRCT
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Skin Rash / IrritationCertaintyLowSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →VomitingCertaintyLowSourceRCT
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →Dry MouthCertaintyLowSourceClinical
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Blood Pressure DecreaseCertaintyLowSourceReference knowledge
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Blood Sugar DecreaseCertaintyLowSourceReference knowledge
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Gout FlareCertaintyLowSourceReference knowledge
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Kidney Stone Formation RiskCertaintyLowSourceReference knowledge
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Nutrient DepletionCertaintyLowSourceReference knowledge
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →Blood Pressure IncreaseCertaintyLowSourceReview
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Fluid Loss (Diuretic Effect)CertaintyLowSourceReview
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Heart Rate IncreaseCertaintyLowSourceReview
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →Inflammation IncreaseCertaintyLowSourceReview
This outcome comes from Omega-3 and Curcumin, with two independent members contributing it; it is not a finding for the combination as a unit.
- →IrritabilityCertaintyLowSourceReview
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Kidney Function DecreaseCertaintyLowSourceReview
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Liver Load IncreaseCertaintyLowSourceReview
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Stool Color ChangeCertaintyLowSourceReview
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Physical FatigueCertaintyLowSourceAnecdotal
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Joint Pain (Arthralgia)CertaintyLowSourceAnecdotal
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Menstrual Cycle ChangesCertaintyLowSourceAnecdotal
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Garlic Breath/Body OdorCertaintyLowSourceAnecdotal
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →PainCertaintyLowSourceAnecdotal
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Paresthesia (Tingling/Numbness)CertaintyLowSourceAnecdotal
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
Very low probability(8)
- →Heart Rate DecreaseCertaintyVery lowSourceRCT
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Prostate Cancer Risk IncreaseCertaintyVery lowSourceRCT
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Hepatotoxicity (Liver Toxicity)CertaintyVery lowSourceReview
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Anxiety IncreaseCertaintyVery lowSourceAnecdotal
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Brain FogCertaintyVery lowSourceAnecdotal
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →InsomniaCertaintyVery lowSourceAnecdotal
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
- →Libido DecreaseCertaintyVery lowSourceAnecdotal
This outcome is attributed to Curcumin alone; it is not a finding for the combination as a unit.
- →Fishy Body OdorCertaintyVery lowSourceAnecdotal
This outcome is attributed to Omega-3 alone; it is not a finding for the combination as a unit.
Don't take it if
Conditions and states that rule it out12 listedHighest probability
- →Bile Duct ObstructionCertaintyHighSourceReference knowledgeSerious
This row comes from Curcumin alone. Curcumin stimulates bile production, which may worsen an existing bile duct obstruction.
- →Bleeding DisordersCertaintyHighSourceReference knowledgeSerious
This concern is shared by two independent members—Omega-3 and Curcumin—rather than being carried by just one member. Omega-3 antiplatelet effects can worsen bleeding tendency in hemophilia, von Willebrand disease, or thrombocytopenia, so use requires specialist supervision and monitoring.
- →CholecystitisCertaintyHighSourceReference knowledgeSerious
This row comes from Curcumin alone. Human ultrasound studies show that Curcumin contracts the gallbladder, which may provoke biliary pain or worsen obstruction during active gallbladder inflammation.
- →Food AllergiesCertaintyHighSourceReference knowledgeSerious
This concern comes from Omega-3 alone, not from a finding about the combination. People with a confirmed fish allergy should avoid fish-derived omega-3 products unless an allergy clinician specifically clears their use; algal EPA or DHA may provide a non-fish alternative.
- →GallstonesCertaintyHighSourceReference knowledgeSerious
This row comes from Curcumin alone. Curcumin's choleretic effects may worsen gallstone symptoms or trigger biliary colic.
- →Pre-SurgeryCertaintyHighSourceReference knowledgeSerious
This concern is shared by two independent members—Omega-3 and Curcumin—rather than being carried by just one member. Omega-3 should be discontinued 7-14 days before elective surgery because of increased bleeding risk during and after procedures.
Medium probability(6)
- →Iron Deficiency AnemiaCertaintyMediumSourceReference knowledgeCaution
This row comes from Curcumin alone. Curcumin can bind ferric iron and impair intestinal iron availability; a case report linked chronic high turmeric intake with iron-deficiency anemia that did not respond to oral iron.
- →Atrial FibrillationCertaintyMediumSourceReference knowledgeCaution
This concern comes from Omega-3 alone. Prescription-strength omega-3 doses around 4 g/day have increased atrial fibrillation or flutter events and recurrence, with greater absolute risk in people with prior atrial fibrillation; this is not established for ordinary dietary doses.
- →Kidney StonesCertaintyMediumSourceReference knowledgeCaution
This row comes from Curcumin alone. Curcumin contains oxalates that may increase urinary oxalate excretion and stone-formation risk in susceptible individuals.
- →Liver Disease (General)CertaintyMediumSourceReference knowledgeCaution
This row comes from Curcumin alone. Curcumin supplements have rarely caused clinically apparent acute liver injury, particularly in enhanced-bioavailability formulations, so active liver disease or previous curcumin-associated liver injury is a relevant caveat.
- →PediatricCertaintyMediumSourceReference knowledgeCaution
This row comes from Curcumin alone. The safety and appropriate dosing of concentrated Curcumin supplements have not been established in children.
- →PregnancyCertaintyMediumSourceReference knowledgeCaution
This row comes from Curcumin alone. High-dose Curcumin may stimulate uterine contractions, and safety during pregnancy is not established.
Emergent cautions
Cautions specific to taking these items togetherInteractions
What changes when it is combined with something elseDangerous combinations
Highest severity first
- →Antiplatelet AgentsSerious
Combined use with antiplatelet agents (aspirin, clopidogrel, ticagrelor) increases bleeding risk through additive antiplatelet effects. Clinical monitoring for bruising and bleeding recommended.
- →TacrolimusSerious
A case report has suggested that heavy turmeric intake may be associated with increased tacrolimus trough concentrations and calcineurin-inhibitor nephrotoxicity; a formulation- and dose-dependent interaction is possible, so therapeutic-drug monitoring may be warranted.
- →WarfarinSerious
High-dose omega-3 can potentiate warfarin's anticoagulant effect, leading to elevated INR and increased bleeding risk; close monitoring is required.
Use with care
Highest probability
- →Antidiabetic / Diabetes MedicationsCaution
Curcumin may lower blood glucose and could increase hypoglycemia risk when combined with diabetes medications
- →BenzodiazepinesCaution
Curcumin has limited evidence for affecting CYP3A4 substrates such as midazolam; a pharmacokinetic interaction with some benzodiazepines is possible, but clinical relevance and respiratory effects are uncertain.
- →Bile Acid SequestrantsCaution
Bile acid sequestrants (cholestyramine, colestipol) can reduce omega-3 absorption by binding bile acids necessary for fat emulsification and micelle formation.
- →CyclosporineCaution
Curcumin may theoretically inhibit CYP3A4 and could affect cyclosporine exposure depending on formulation and dose; monitor levels if used together.
- →Digoxin (Cardiac Glycoside)Caution
Curcumin may theoretically affect P-glycoprotein activity, so digoxin exposure could be altered in some settings; clinical relevance at typical oral doses is uncertain.
- →SupplementsGarlicCaution
Garlic has antiplatelet effects; concurrent use with omega-3 may additively increase bleeding risk.
- →SupplementsGinkgo BilobaCaution
Both omega-3 and ginkgo biloba inhibit platelet aggregation; combined use may increase the risk of bleeding, particularly in susceptible individuals.
Unrated(5)
- →Orlistat (Lipase Inhibitor)Caution
Orlistat may reduce absorption of omega-3 fatty acids and other fat-soluble nutrients. Use clinician or pharmacist guidance rather than unsupervised dose increases.
- →Statins (HMG-CoA Reductase Inhibitors)Caution
Curcumin may theoretically inhibit CYP3A4 and affect exposure to some CYP3A4-metabolized statins, depending on product formulation and dose; clinically important toxicity is not established.
- →SulfasalazineCaution
Curcumin inhibited intestinal BCRP in a healthy-volunteer study and increased sulfasalazine exposure approximately threefold, potentially increasing dose-related toxicity.
- →Tamoxifen (SERM)Caution
Human pharmacokinetic evidence suggests curcumin may reduce endoxifen exposure in some formulations or doses; this is a formulation-dependent interaction and oncology supervision is advised.
- →TheophyllineCaution
Curcumin may theoretically inhibit CYP1A2, so theophylline exposure could be altered in some formulations or doses; clinical relevance in humans is uncertain.