Digoxin (Cardiac Glycoside)
Explore interaction information for Digoxin (Cardiac Glycoside), also known as Lanoxin. Use this page to review compatibility questions involving another product.
1 supplements in this library have a recorded interaction with this medication
Dangerous combinations
Supplements recorded as risky with this medication1 listedHighest severity first
- →SupplementsSea Moss (Irish Moss)TheoreticalCaution
Sea moss may affect serum potassium, and potassium abnormalities can influence digoxin toxicity; however, sea moss is not established to alter potassium enough to change digoxin effect.
Where the evidence comes from
- Reference knowledge
Open Sea Moss (Irish Moss)Confidence
confidence 55/100
- Trade names
- Digoxin (Lanoxin)
Full write-up
What is it
Digoxin (Cardiac Glycoside) is a cardiovascular drug in the cardiac glycoside family. It is also known by the brand name Lanoxin.
This page is an educational reference for reviewing compatibility questions involving other products that may be taken alongside it. For questions related to a medical condition or treatment, consult a clinician.
What interacts with it
The most important concerns involve changes in potassium or calcium, because electrolyte disturbances can increase digoxin-related cardiac risk. Aloe Vera, Apple Cider Vinegar, and Sodium Bicarbonate may lower potassium, which can increase susceptibility to digoxin toxicity; Sodium Bicarbonate may also alter digoxin excretion. Calcium and excessive Cod Liver Oil may contribute to elevated blood calcium, increasing cardiac sensitivity to digoxin. Potassium itself is not inherently harmful, but both low and high potassium can affect safety, particularly when kidney function is impaired. Potassium replacement or supplementation therefore warrants clinical guidance.
Some supplements may alter digoxin exposure. Berberine can inhibit P-glycoprotein and significantly increase blood levels. Quercetin may have a similar effect, while CBD (Cannabidiol) may increase oral exposure. These concerns matter because digoxin has a narrow therapeutic index. St. John's Wort may reduce digoxin concentrations, particularly with high-hyperforin extracts. Curcumin may theoretically affect P-glycoprotein, although the clinical relevance at typical oral doses is uncertain.
Dietary Fiber (Prebiotics) and Psyllium Husk can reduce digoxin absorption through binding or adsorption, potentially weakening its effect. Their administration may need to be separated, with clinical monitoring when fiber supplementation is started or stopped. Bacopa Monnieri may add to digoxin's effects on cardiac conduction. Panax Ginseng and high-dose Vitamin B7 (Biotin) can interfere with some digoxin blood tests, potentially producing misleading results rather than changing digoxin levels themselves.
Because both excessive exposure and reduced absorption can be consequential, discuss these combinations with a prescriber or pharmacist, especially when a supplement is started, stopped, or changed.