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Pain

Chronic Pain

Chronic Pain is a health topic within the pain category. The outcome discussed is chronic pain intensity, meaning how strong the pain feels.

Chronic Pain sits within the pain category, offering a focused starting point for understanding this health topic.

This list shows research findings, not treatments. Nothing here replaces medical care. If you have this condition, talk to a doctor.

What may help

What studies found for each option, best evidence first.

29 options:1 good evidence6 some evidence12 not enough evidence9 not tested in people1 no benefit found

  • Hatha YogapracticeGood evidence it helpsSize of effect: Not known

    Good human studies found a benefit, and they mostly agree. This is about what studies measured, not a cure.

    All 4 studies with a clear result found a benefit.

    A 12-week trial involving 140 people found improvements in pain intensity and back-related function versus a wait-list control, maintained at 24 weeks, alongside reduced analgesic use and improved sleep quality. In a pilot trial of 40 people with chronic pain receiving opioid agonist therapy, pain and mood improved more in the yoga group.

    Open the Hatha Yoga page
  • Acceptance and Commitment Therapy (ACT)practiceSome evidence it helpsSize of effect: Not known

    Some human studies found a benefit. More research could change this.

    All 11 studies with a clear result found a benefit.

    Pooled randomized trials in adults with chronic pain found improvements favoring ACT in pain acceptance, functioning, pain intensity and mood. Other pooled findings reported pain relief, increased pain acceptance and reduced post-surgical analgesic use, although ACT was not consistently superior to other behavioral therapies.

    Open the Acceptance and Commitment Therapy (ACT) page
  • MassagepracticeSome evidence it helpsSize of effect: Not known

    Some human studies found a benefit. More research could change this.

    All 2 studies with a clear result found a benefit.

    A pooled analysis whose study designs were not recorded reported a reduction in pain scores. A review also found that changes in brain activity tracked with pain relief and symptom improvement.

    Open the Massage page
  • MeditationpracticeSome evidence it helpsSize of effect: Not known

    Some human studies found a benefit. More research could change this.

    All 6 studies with a clear result found a benefit.

    A two-arm trial of 52 people compared 12 sessions of virtual-reality mindfulness with standard care and reported g=1.33 for pain and disability. A review also found reduced pain severity or interference across studies involving low back pain, headache, and chronic neuropathic pain.

    Open the Meditation page
  • Mindfulness MeditationpracticeSome evidence it helpsSize of effect: Not known

    Some human studies found a benefit. More research could change this.

    All 6 studies with a clear result found a benefit.

    A review of 4 studies found improvements in emotional regulation and control over pain, but reductions in pain intensity were inconsistent. In a separate RCT, changes in willingness, valued activities, and catastrophizing were associated with reduced pain intensity and interference; the finding does not establish a direct mindfulness effect on pain outcomes.

    Open the Mindfulness Meditation page
  • YogapracticeSome evidence it helpsSize of effect: Large

    Some human studies found a benefit. More research could change this.

    6 of 7 studies found a benefit; 1 found none.

    A pooled analysis of 8 randomized trials reported reduced labor pain with prenatal Yoga/reflexology. For chronic low back pain, another pooled analysis reported better physical function and emotional wellbeing than active exercise, but no significant between-group difference in pain or disability; a separate review described limited support for pain management.

    Open the Yoga page
  • Cupping TherapypracticeSome evidence it helpsSize of effect: Large

    Some human studies found a benefit. More research could change this.

    All 4 studies with a clear result found a benefit.

    Open the Cupping Therapy page
  • AcupuncturepracticeNot enough evidence

    Too few or too small studies to know if it works.

    The one study found a benefit.

    Across 17 randomized trials of chronic pain, pooled VAS scores and pain relief rates improved with acupuncture.

    Open the Acupuncture page

The expert view shows every study, dose protocol and source.

What may help

Interventions recorded as helping with this condition29 listed

Highest probability, strongest evidence

  1. PracticesHatha YogaCertaintyHighSourceClinical

    A 12-week trial involving 140 people found improvements in pain intensity and back-related function versus a wait-list control, maintained at 24 weeks, alongside reduced analgesic use and improved sleep quality. In a pilot trial of 40 people with chronic pain receiving opioid agonist therapy, pain and mood improved more in the yoga group.

    Who was studied

    • People with a condition
    • Back Pain
    • Chronic Pain

    Study result

    12-week RCT showing significant improvements in pain intensity (NRS) and back-related function (RMDQ) vs wait-list control, maintained at 24 weeks, with reduced analgesic use and improved sleep quality

    Open Hatha Yoga
    →
Medium probability(6)
  1. PracticesAcceptance and Commitment Therapy (ACT)CertaintyMediumSourceMeta-analysis

    Pooled randomized trials in adults with chronic pain found improvements favoring ACT in pain acceptance, functioning, pain intensity and mood. Other pooled findings reported pain relief, increased pain acceptance and reduced post-surgical analgesic use, although ACT was not consistently superior to other behavioral therapies.

    Who was studied

    • People with a condition
    • Cancer
    • Diabetes
    • Obesity

    Study result

    Pooled RCTs in adults with chronic pain showed improved pain acceptance, functioning, pain intensity, and mood outcomes favoring ACT.

    Open Acceptance and Commitment Therapy (ACT)
    →
  2. PracticesMassageCertaintyMediumSourceRCT

    A pooled analysis whose study designs were not recorded reported a reduction in pain scores (VAS reduction −16.01, 95% CI −19.35 to −12.68). A review also found that changes in brain activity tracked with pain relief and symptom improvement.

    Who was studied

    • Healthy people and patients

    Study result

    20 studies focused on pain symptom relief; pooled VAS reduction of −16.01 (95% CI −19.35 to −12.68)

    Open Massage
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  3. PracticesMeditationCertaintyMediumSourceRCT

    A two-arm trial of 52 people compared 12 sessions of virtual-reality mindfulness with standard care and reported g=1.33 for pain and disability. A review also found reduced pain severity or interference across studies involving low back pain, headache, and chronic neuropathic pain.

    Who was studied

    • Healthy people and patients
    • Headache Disorder
    • Migraine

    Study result

    McConnell et al (2024) 2-arm RCT (n=52), VR mindfulness 12 sessions vs standard care, g=1.33 for pain/disability; reported in Table 1 but not pooled across the review

    Open Meditation
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  4. PracticesMindfulness MeditationCertaintyMediumSourceRCT

    A review of 4 studies found improvements in emotional regulation and control over pain, but reductions in pain intensity were inconsistent. In a separate RCT, changes in willingness, valued activities, and catastrophizing were associated with reduced pain intensity and interference; the finding does not establish a direct mindfulness effect on pain outcomes.

    Who was studied

    • People with a condition

    Study result

    Systematic review of 4 studies testing mindfulness-based treatments (VAMDB, MBCT, MBSR, MBPM) in chronic pain populations; promising EEG correlates and improved emotional regulation/control over pain emerged, though pain intensity reductions were inconsistent (no significant pain reduction in Brown

    Open Mindfulness Meditation
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  5. PracticesYogaCertaintyMediumSourceRCTLarge effect

    A pooled analysis of 8 randomized trials (n = 448) reported reduced labor pain with prenatal Yoga/reflexology (SMD −1.13; 95% CI −1.99 to −0.27). For chronic low back pain, another pooled analysis reported better physical function and emotional wellbeing than active exercise, but no significant between-group difference in pain or disability; a separate review described limited support for pain management.

    How big is the effect

    Large effectA big difference on average. Check how strong the evidence is.

    Who was studied

    • People with a condition
    • Anxiety Disorder
    • Arthritis
    • Back Pain
    • Cancer
    • Chronic Fatigue Syndrome
    • Chronic Pain
    • +4 more

    Study result

    Meta-analysis of 8 RCTs (n = 448) found significant reduction in labor pain (SMD −1.13; 95% CI −1.99 to −0.27) with prenatal yoga/reflexology.

    Open Yoga
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  6. PracticesCupping TherapyCertaintyMediumSourceClinicalLarge effect

    A 2023 systematic review pooling randomized and non-randomized human studies reported a large effect on chronic pain (SMD −1.03 [−1.41, −0.65]). An earlier review said that although most studies suggested potential benefit across pain conditions, the evidence was insufficient for a recommendation.

    How big is the effect

    Large effectA big difference on average. Check how strong the evidence is.

    Who was studied

    • People with a condition
    • Acne
    • Asthma
    • Chronic Pain
    • Common Cold
    • Herpes Zoster

    Study result

    One moderate-quality evidence from Cramer et al. (SMD −1.03 [−1.41, −0.65])

    Open Cupping Therapy
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Low probability(21)
  1. PracticesAcupunctureCertaintyLowSourceRCT

    Across 17 randomized trials of chronic pain, pooled VAS scores and pain relief rates improved with acupuncture.

    Who was studied

    • People with a condition
    • Back Pain
    • Migraine
    • Osteoarthritis

    Study result

    Pooled VAS and pain relief rate improved with acupuncture across 17 RCTs of chronic pain

    Open Acupuncture
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  2. PracticesHigh-Intensity Interval Training (HIIT)CertaintyLowSourceRCT

    A 2025 review reported reduced pain with HIIT in musculoskeletal disorders and cancer-related pain.

    Who was studied

    • Healthy people and patients
    • Asthma
    • Cancer
    • Chronic Pain
    • Copd
    • Coronary Artery Disease
    • Diabetes Type1
    • +6 more

    Study result

    HIIT decreases pain in musculoskeletal disorders and cancer-related pain.

    Open High-Intensity Interval Training (HIIT)
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  3. PracticesForest Bathing (Shinrin-yoku)CertaintyLowSourceClinical

    In a non-randomized comparative study of 61 people, the forest therapy group had improvements in pain and quality of life compared with the control group. A review also described studies reporting decreased pain and fewer trigger points.

    Who was studied

    • Healthy people and patients
    • Anxiety Disorder
    • Cancer
    • Chronic Pain
    • Copd
    • Coronary Artery Disease
    • Depression
    • +2 more

    Study result

    Significant improvements in pain, depression, HRV, NK cell activity, and quality of life in the forest therapy group compared to control in this non-randomized comparative study.

    Open Forest Bathing (Shinrin-yoku)
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  4. PracticesInfrared SaunaCertaintyLowSourceClinical

    A 2009 review drawing on randomized and non-randomized human studies considered people with chronic pain alongside groups with coronary artery disease, heart failure, and obesity.

    Who was studied

    • Healthy people and patients
    • Chronic Pain
    • Coronary Artery Disease
    • Heart Failure
    • Obesity

    Study result

    Fair evidence from a single study (review abstract)

    Open Infrared Sauna
    →
  5. PracticesLaughter Yoga / TherapyCertaintyLowSourceClinical

    A review reported alleviation of pain and fatigue in children, including children with cancer.

    Who was studied

    • People with a condition
    • Cancer
    • Eczema

    Study result

    Studies reported alleviation of pain and fatigue in children, including those with cancer.

    Open Laughter Yoga / Therapy
    →
  6. PracticesLoving-Kindness Meditation (Metta)CertaintyLowSourceClinical

    In a 2014 pilot study of 12 people with chronic pain, pain severity and anger decreased after the intervention, while pain acceptance increased.

    Who was studied

    • People with a condition

    Study result

    Pilot study showing significant reductions in pain severity and anger, and increased pain acceptance post-intervention.

    Open Loving-Kindness Meditation (Metta)
    →
  7. PracticesPilatesCertaintyLowSourceClinical

    A 2026 trial in 30 office workers with chronic neck pain (VAS >3/10, >6 weeks) found improvements in pain, disability and function. A review of randomized and non-randomized studies found the evidence inconclusive for chronic low back pain, so findings may differ by pain site.

    Who was studied

    • People with a condition
    • Chronic Pain

    Study result

    Study population of office workers with chronic neck pain (VAS >3/10, >6 weeks) in which Pilates produced pain, disability and function improvements.

    Open Pilates
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  8. PracticesQigongCertaintyLowSourceClinical

    In a cluster randomized trial, older adults with chronic pain had greater posttest pain improvement with Qigong Wuqinxi than with usual care.

    Who was studied

    • People with a condition

    Study result

    Older adults with chronic pain showed greater posttest pain improvement with Qigong Wuqinxi than usual-care controls in a cluster RCT.

    Open Qigong
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  9. PracticesRed Light Therapy (Photobiomodulation)CertaintyLowSourceClinical

    A randomized trial of 52 adults with chronic trapezius pain and confirmed myofascial trigger points found mixed results: function improved, but pain did not.

    Who was studied

    • People with a condition
    • Chronic Pain

    Study result

    Trial enrolled adults with chronic trapezius pain and confirmed myofascial trigger points; LLLT was tested as a treatment for this condition, with mixed results (functional improvement, no pain effect).

    Open Red Light Therapy (Photobiomodulation)
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  10. PracticesSwedish (Classic) MassageCertaintyLowSourceClinical

    A pilot RCT involving 29 people with chronic pain conditions found that massage improved pain compared with standard care. The finding comes from a pilot sample and does not specify which chronic pain conditions benefited.

    Who was studied

    • People with a condition
    • Chronic Pain

    Study result

    Pragmatic RCT in patients with chronic pain conditions; massage improved pain relative to standard care in a pilot sample.

    Open Swedish (Classic) Massage
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  11. PracticesSwimmingCertaintyLowSourceClinical

    An RCT with 34 participants found within-group improvements in paraspinal muscle volume and strength after aquatic therapy.

    Study result

    RCT with 34 participants showing significant within-group improvements in paraspinal muscle volume and strength after aquatic therapy.

    Open Swimming
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  12. PracticesVinyasa YogaCertaintyLowSourceClinical

    A 2024 pilot evaluated Yoga for chronic pain among women in substance use rehabilitation; no pain outcome result is reported here.

    Who was studied

    • People with a condition

    Study result

    Study population selected for chronic pain among women in substance use rehabilitation; pain was the target of the intervention evaluation.

    Open Vinyasa Yoga
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  13. PracticesHot YogaCertaintyLowSourceTheoretical

    Bikram Yoga may help manage chronic low back pain and musculoskeletal discomfort through improved flexibility, body awareness, and stress modulation.

    Study result

    May help manage chronic low back pain and musculoskeletal discomfort through improved flexibility, body awareness, and stress modulation.

    Open Hot Yoga
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  14. PracticesFinnish SaunaCertaintyLowSourceTheoretical

    Sauna therapy is proposed to ease chronic pain through muscle relaxation, improved circulation and endorphin release, and is used in multimodal pain programs.

    Study result

    Sauna therapy reduces chronic pain through muscle relaxation, improved circulation, and endorphin release, and is used in multimodal pain programs.

    Open Finnish Sauna
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  15. PracticesFocused Attention MeditationCertaintyLowSourceTheoretical

    Focused attention meditation is described as helping reduce pain-related distress and improve coping through attentional control and acceptance.

    Study result

    Effective in reducing pain-related distress and improving pain coping through enhanced attentional control and acceptance.

    Open Focused Attention Meditation
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  16. PracticesGardening TherapyCertaintyLowSourceTheoretical

    Gardening therapy is proposed to help with chronic pain through distraction, physical activity and improved mood.

    Study result

    Gardening therapy reduces chronic pain through distraction, physical activity, and improved mood.

    Open Gardening Therapy
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  17. PracticesGratitude JournalCertaintyLowSourceTheoretical

    Gratitude journaling may improve pain coping and reduce pain catastrophizing, though its effects on pain intensity are modest.

    Study result

    Gratitude journaling may improve pain coping and reduce pain catastrophizing, though effects on pain intensity are modest.

    Open Gratitude Journal
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  18. PracticesHot BathCertaintyLowSourceTheoretical

    Hot baths are described as a non-pharmacological approach to managing discomfort associated with chronic low back pain, osteoarthritis, and fibromyalgia.

    Study result

    Hot baths are a non-pharmacological intervention for managing chronic low back pain, osteoarthritis, and fibromyalgia-related discomfort.

    Open Hot Bath
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  19. PracticesPsychotherapyCertaintyLowSourceTheoretical

    Cognitive behavioral therapy may improve pain coping and function in chronic pain, independently of changes in nociception.

    Study result

    Cognitive-behavioral therapy improves pain coping and function in chronic pain, independent of nociceptive changes.

    Open Psychotherapy
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  20. PracticesStrength TrainingCertaintyLowSourceTheoretical

    Supervised resistance training modestly reduces pain and improves function in chronic musculoskeletal pain; effects are small to moderate and vary by condition.

    Study result

    Supervised resistance training modestly reduces pain and improves function in chronic musculoskeletal pain. Effect sizes are small to moderate and vary by condition.

    Open Strength Training
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  21. PracticesYin YogaCertaintyLowSourceTheoretical

    Yin Yoga’s gentle, sustained stretching and mindfulness may help manage chronic pain by reducing central sensitization and improving fascial mobility, though robust evidence is lacking.

    Study result

    Yin yoga's gentle, sustained stretching and mindfulness component may help manage chronic pain conditions by reducing central sensitization and improving fascial mobility, though robust evidence is lacking.

    Open Yin Yoga
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Very low probability(1)
  1. PracticesBinaural BeatsCertaintyVery lowSourceRCT

    A 2024 systematic review of randomized trials found no effect on chronic pain, and the studies did not support this use.

    Who was studied

    • People with a condition
    Open Binaural Beats
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What to avoid

Interventions recorded as making it worse

Nothing in this library is currently recorded as making Chronic Pain worse. Coverage is partial, and absence here is not evidence of safety.

Browse the supplements that are written up

How to read the evidence

Evidence tier — overall strength of the evidence for the whole compound

  • StrongWell established — backed by strong, consistent human research.
  • ModerateSome genuine support, but mostly from small or lower-quality studies. Promising, not proven.
  • PreliminaryEarly-stage evidence — a promising hypothesis, not an established effect yet.
  • LimitedVery limited evidence — treat this as a hypothesis, not proof.
  • InsufficientNot enough good evidence to draw conclusions yet.

Certainty — how sure we can be that the effect is real

  • Very highVery sure — strong, consistent evidence
  • HighFairly sure — consistent evidence from good studies
  • MediumModerately sure — new studies could change this
  • LowNot sure — little or mixed evidence
  • Very lowVery unsure — almost no usable evidence

Source — where the data comes from

  • Meta-analysisPooled analysis of many trials — the strongest evidence
  • RCTRandomized controlled trial — a strong human study design
  • ClinicalA human clinical study
  • Reference knowledgeFrom general health-science or pharmacology references, not a study of this exact claim
  • Animal researchStudied in animals, not humans
  • Community reportsAggregated user reports — anecdotal signal, not evidence
  • TheoreticalMechanism-based reasoning, not yet tested

Study grade — quality of each underlying study (A best, D weakest)

  • AHigh-quality — strong, consistent human trials
  • BGood — solid evidence with some limitations
  • CModerate — limited, small, or mixed-quality studies
  • DWeak — preliminary, indirect, or animal-only

Confidence — how strongly the sources back a finding

A 0–100 score from study quality and agreement

Most supplement evidence is graded C–D. Read it as preliminary signal, not proof.

Full write-up

What is it

Chronic Pain is a health topic within the pain category. The outcome discussed is chronic pain intensity, meaning how strong the pain feels. It provides a focused starting point for understanding pain-related concerns; specific causes, patterns, and treatment considerations may differ between people.

Evidence-backed options

The options associated with Chronic Pain are not interchangeable. They include supplements, mind-body practices, and sauna-based approaches, with evidence ranging from randomized controlled trials and clinical findings to reviews, pharmacology references, and animal research. Omega-3 has the clearest supportive finding among the options described, while evidence for the other approaches is generally more limited or applies to narrower situations.

The populations and pain contexts studied differ. Some findings concern chronic pain broadly, while others relate to musculoskeletal conditions, postoperative spinal pain, or pain associated with a herniated disc. Quercetin is supported only by animal research, so its findings do not directly establish effects in people. CBD remains incompletely established despite promising outcomes in many studies. Yoga findings are also qualified by substantial variation between studies, which limits certainty about the overall result.

No single dose, treatment duration, or time to onset is established across these options in the available summaries. The findings therefore describe different interventions and contexts rather than one standardized approach to Chronic Pain. A clinician can help interpret whether evidence from a particular pain condition or study population is relevant to an individual situation.

Diatelos provides general wellness information based on published research. It is not medical advice. Talk to a clinician before starting any new supplement or practice, especially if you have a health condition, are pregnant, or take medication.