Pain
Chronic Pain
Chronic Pain is a health topic within the pain category. The outcome discussed is chronic pain intensity, meaning how strong the pain feels.
Chronic Pain sits within the pain category, offering a focused starting point for understanding this health topic.
This list shows research findings, not treatments. Nothing here replaces medical care. If you have this condition, talk to a doctor.
What may help
What studies found for each option, best evidence first.
29 options:1 good evidence6 some evidence12 not enough evidence9 not tested in people1 no benefit found
Hatha YogapracticeGood evidence it helpsSize of effect: Not known
Good human studies found a benefit, and they mostly agree. This is about what studies measured, not a cure.
All 4 studies with a clear result found a benefit.
A 12-week trial involving 140 people found improvements in pain intensity and back-related function versus a wait-list control, maintained at 24 weeks, alongside reduced analgesic use and improved sleep quality. In a pilot trial of 40 people with chronic pain receiving opioid agonist therapy, pain and mood improved more in the yoga group.
Open the Hatha Yoga pageAcceptance and Commitment Therapy (ACT)practiceSome evidence it helpsSize of effect: Not known
Some human studies found a benefit. More research could change this.
All 11 studies with a clear result found a benefit.
Pooled randomized trials in adults with chronic pain found improvements favoring ACT in pain acceptance, functioning, pain intensity and mood. Other pooled findings reported pain relief, increased pain acceptance and reduced post-surgical analgesic use, although ACT was not consistently superior to other behavioral therapies.
Open the Acceptance and Commitment Therapy (ACT) pageMassagepracticeSome evidence it helpsSize of effect: Not known
Some human studies found a benefit. More research could change this.
All 2 studies with a clear result found a benefit.
A pooled analysis whose study designs were not recorded reported a reduction in pain scores. A review also found that changes in brain activity tracked with pain relief and symptom improvement.
Open the Massage pageMeditationpracticeSome evidence it helpsSize of effect: Not known
Some human studies found a benefit. More research could change this.
All 6 studies with a clear result found a benefit.
A two-arm trial of 52 people compared 12 sessions of virtual-reality mindfulness with standard care and reported g=1.33 for pain and disability. A review also found reduced pain severity or interference across studies involving low back pain, headache, and chronic neuropathic pain.
Open the Meditation pageMindfulness MeditationpracticeSome evidence it helpsSize of effect: Not known
Some human studies found a benefit. More research could change this.
All 6 studies with a clear result found a benefit.
A review of 4 studies found improvements in emotional regulation and control over pain, but reductions in pain intensity were inconsistent. In a separate RCT, changes in willingness, valued activities, and catastrophizing were associated with reduced pain intensity and interference; the finding does not establish a direct mindfulness effect on pain outcomes.
Open the Mindfulness Meditation pageYogapracticeSome evidence it helpsSize of effect: Large
Some human studies found a benefit. More research could change this.
6 of 7 studies found a benefit; 1 found none.
A pooled analysis of 8 randomized trials reported reduced labor pain with prenatal Yoga/reflexology. For chronic low back pain, another pooled analysis reported better physical function and emotional wellbeing than active exercise, but no significant between-group difference in pain or disability; a separate review described limited support for pain management.
Open the Yoga pageCupping TherapypracticeSome evidence it helpsSize of effect: Large
Some human studies found a benefit. More research could change this.
All 4 studies with a clear result found a benefit.
Open the Cupping Therapy pageAcupuncturepracticeNot enough evidence
Too few or too small studies to know if it works.
The one study found a benefit.
Across 17 randomized trials of chronic pain, pooled VAS scores and pain relief rates improved with acupuncture.
Open the Acupuncture page
The expert view shows every study, dose protocol and source.
What may help
Interventions recorded as helping with this condition29 listedHighest probability, strongest evidence
- →PracticesHatha YogaCertaintyHighSourceClinical
A 12-week trial involving 140 people found improvements in pain intensity and back-related function versus a wait-list control, maintained at 24 weeks, alongside reduced analgesic use and improved sleep quality. In a pilot trial of 40 people with chronic pain receiving opioid agonist therapy, pain and mood improved more in the yoga group.
Who was studied
- People with a condition
- Back Pain
- Chronic Pain
Open Hatha YogaStudy result
12-week RCT showing significant improvements in pain intensity (NRS) and back-related function (RMDQ) vs wait-list control, maintained at 24 weeks, with reduced analgesic use and improved sleep quality
Medium probability(6)
- →PracticesAcceptance and Commitment Therapy (ACT)CertaintyMediumSourceMeta-analysis
Pooled randomized trials in adults with chronic pain found improvements favoring ACT in pain acceptance, functioning, pain intensity and mood. Other pooled findings reported pain relief, increased pain acceptance and reduced post-surgical analgesic use, although ACT was not consistently superior to other behavioral therapies.
Who was studied
- People with a condition
- Cancer
- Diabetes
- Obesity
Open Acceptance and Commitment Therapy (ACT)Study result
Pooled RCTs in adults with chronic pain showed improved pain acceptance, functioning, pain intensity, and mood outcomes favoring ACT.
- →PracticesMassageCertaintyMediumSourceRCT
A pooled analysis whose study designs were not recorded reported a reduction in pain scores (VAS reduction −16.01, 95% CI −19.35 to −12.68). A review also found that changes in brain activity tracked with pain relief and symptom improvement.
Who was studied
- Healthy people and patients
Open MassageStudy result
20 studies focused on pain symptom relief; pooled VAS reduction of −16.01 (95% CI −19.35 to −12.68)
- →PracticesMeditationCertaintyMediumSourceRCT
A two-arm trial of 52 people compared 12 sessions of virtual-reality mindfulness with standard care and reported g=1.33 for pain and disability. A review also found reduced pain severity or interference across studies involving low back pain, headache, and chronic neuropathic pain.
Who was studied
- Healthy people and patients
- Headache Disorder
- Migraine
Open MeditationStudy result
McConnell et al (2024) 2-arm RCT (n=52), VR mindfulness 12 sessions vs standard care, g=1.33 for pain/disability; reported in Table 1 but not pooled across the review
- →PracticesMindfulness MeditationCertaintyMediumSourceRCT
A review of 4 studies found improvements in emotional regulation and control over pain, but reductions in pain intensity were inconsistent. In a separate RCT, changes in willingness, valued activities, and catastrophizing were associated with reduced pain intensity and interference; the finding does not establish a direct mindfulness effect on pain outcomes.
Who was studied
- People with a condition
Open Mindfulness MeditationStudy result
Systematic review of 4 studies testing mindfulness-based treatments (VAMDB, MBCT, MBSR, MBPM) in chronic pain populations; promising EEG correlates and improved emotional regulation/control over pain emerged, though pain intensity reductions were inconsistent (no significant pain reduction in Brown
- →PracticesYogaCertaintyMediumSourceRCTLarge effect
A pooled analysis of 8 randomized trials (n = 448) reported reduced labor pain with prenatal Yoga/reflexology (SMD −1.13; 95% CI −1.99 to −0.27). For chronic low back pain, another pooled analysis reported better physical function and emotional wellbeing than active exercise, but no significant between-group difference in pain or disability; a separate review described limited support for pain management.
How big is the effect
Large effectA big difference on average. Check how strong the evidence is.
Who was studied
- People with a condition
- Anxiety Disorder
- Arthritis
- Back Pain
- Cancer
- Chronic Fatigue Syndrome
- Chronic Pain
- +4 more
Open YogaStudy result
Meta-analysis of 8 RCTs (n = 448) found significant reduction in labor pain (SMD −1.13; 95% CI −1.99 to −0.27) with prenatal yoga/reflexology.
- →PracticesCupping TherapyCertaintyMediumSourceClinicalLarge effect
A 2023 systematic review pooling randomized and non-randomized human studies reported a large effect on chronic pain (SMD −1.03 [−1.41, −0.65]). An earlier review said that although most studies suggested potential benefit across pain conditions, the evidence was insufficient for a recommendation.
How big is the effect
Large effectA big difference on average. Check how strong the evidence is.
Who was studied
- People with a condition
- Acne
- Asthma
- Chronic Pain
- Common Cold
- Herpes Zoster
Open Cupping TherapyStudy result
One moderate-quality evidence from Cramer et al. (SMD −1.03 [−1.41, −0.65])
Low probability(21)
- →PracticesAcupunctureCertaintyLowSourceRCT
Across 17 randomized trials of chronic pain, pooled VAS scores and pain relief rates improved with acupuncture.
Who was studied
- People with a condition
- Back Pain
- Migraine
- Osteoarthritis
Open AcupunctureStudy result
Pooled VAS and pain relief rate improved with acupuncture across 17 RCTs of chronic pain
- →PracticesHigh-Intensity Interval Training (HIIT)CertaintyLowSourceRCT
A 2025 review reported reduced pain with HIIT in musculoskeletal disorders and cancer-related pain.
Who was studied
- Healthy people and patients
- Asthma
- Cancer
- Chronic Pain
- Copd
- Coronary Artery Disease
- Diabetes Type1
- +6 more
Open High-Intensity Interval Training (HIIT)Study result
HIIT decreases pain in musculoskeletal disorders and cancer-related pain.
- →PracticesForest Bathing (Shinrin-yoku)CertaintyLowSourceClinical
In a non-randomized comparative study of 61 people, the forest therapy group had improvements in pain and quality of life compared with the control group. A review also described studies reporting decreased pain and fewer trigger points.
Who was studied
- Healthy people and patients
- Anxiety Disorder
- Cancer
- Chronic Pain
- Copd
- Coronary Artery Disease
- Depression
- +2 more
Open Forest Bathing (Shinrin-yoku)Study result
Significant improvements in pain, depression, HRV, NK cell activity, and quality of life in the forest therapy group compared to control in this non-randomized comparative study.
- →PracticesInfrared SaunaCertaintyLowSourceClinical
A 2009 review drawing on randomized and non-randomized human studies considered people with chronic pain alongside groups with coronary artery disease, heart failure, and obesity.
Who was studied
- Healthy people and patients
- Chronic Pain
- Coronary Artery Disease
- Heart Failure
- Obesity
Open Infrared SaunaStudy result
Fair evidence from a single study (review abstract)
- →PracticesLaughter Yoga / TherapyCertaintyLowSourceClinical
A review reported alleviation of pain and fatigue in children, including children with cancer.
Who was studied
- People with a condition
- Cancer
- Eczema
Open Laughter Yoga / TherapyStudy result
Studies reported alleviation of pain and fatigue in children, including those with cancer.
- →PracticesLoving-Kindness Meditation (Metta)CertaintyLowSourceClinical
In a 2014 pilot study of 12 people with chronic pain, pain severity and anger decreased after the intervention, while pain acceptance increased.
Who was studied
- People with a condition
Open Loving-Kindness Meditation (Metta)Study result
Pilot study showing significant reductions in pain severity and anger, and increased pain acceptance post-intervention.
- →PracticesPilatesCertaintyLowSourceClinical
A 2026 trial in 30 office workers with chronic neck pain (VAS >3/10, >6 weeks) found improvements in pain, disability and function. A review of randomized and non-randomized studies found the evidence inconclusive for chronic low back pain, so findings may differ by pain site.
Who was studied
- People with a condition
- Chronic Pain
Open PilatesStudy result
Study population of office workers with chronic neck pain (VAS >3/10, >6 weeks) in which Pilates produced pain, disability and function improvements.
- →PracticesQigongCertaintyLowSourceClinical
In a cluster randomized trial, older adults with chronic pain had greater posttest pain improvement with Qigong Wuqinxi than with usual care.
Who was studied
- People with a condition
Open QigongStudy result
Older adults with chronic pain showed greater posttest pain improvement with Qigong Wuqinxi than usual-care controls in a cluster RCT.
- →PracticesRed Light Therapy (Photobiomodulation)CertaintyLowSourceClinical
A randomized trial of 52 adults with chronic trapezius pain and confirmed myofascial trigger points found mixed results: function improved, but pain did not.
Who was studied
- People with a condition
- Chronic Pain
Open Red Light Therapy (Photobiomodulation)Study result
Trial enrolled adults with chronic trapezius pain and confirmed myofascial trigger points; LLLT was tested as a treatment for this condition, with mixed results (functional improvement, no pain effect).
- →PracticesSwedish (Classic) MassageCertaintyLowSourceClinical
A pilot RCT involving 29 people with chronic pain conditions found that massage improved pain compared with standard care. The finding comes from a pilot sample and does not specify which chronic pain conditions benefited.
Who was studied
- People with a condition
- Chronic Pain
Open Swedish (Classic) MassageStudy result
Pragmatic RCT in patients with chronic pain conditions; massage improved pain relative to standard care in a pilot sample.
- →PracticesSwimmingCertaintyLowSourceClinical
An RCT with 34 participants found within-group improvements in paraspinal muscle volume and strength after aquatic therapy.
Open SwimmingStudy result
RCT with 34 participants showing significant within-group improvements in paraspinal muscle volume and strength after aquatic therapy.
- →PracticesVinyasa YogaCertaintyLowSourceClinical
A 2024 pilot evaluated Yoga for chronic pain among women in substance use rehabilitation; no pain outcome result is reported here.
Who was studied
- People with a condition
Open Vinyasa YogaStudy result
Study population selected for chronic pain among women in substance use rehabilitation; pain was the target of the intervention evaluation.
- →PracticesHot YogaCertaintyLowSourceTheoretical
Bikram Yoga may help manage chronic low back pain and musculoskeletal discomfort through improved flexibility, body awareness, and stress modulation.
Open Hot YogaStudy result
May help manage chronic low back pain and musculoskeletal discomfort through improved flexibility, body awareness, and stress modulation.
- →PracticesFinnish SaunaCertaintyLowSourceTheoretical
Sauna therapy is proposed to ease chronic pain through muscle relaxation, improved circulation and endorphin release, and is used in multimodal pain programs.
Open Finnish SaunaStudy result
Sauna therapy reduces chronic pain through muscle relaxation, improved circulation, and endorphin release, and is used in multimodal pain programs.
- →PracticesFocused Attention MeditationCertaintyLowSourceTheoretical
Focused attention meditation is described as helping reduce pain-related distress and improve coping through attentional control and acceptance.
Open Focused Attention MeditationStudy result
Effective in reducing pain-related distress and improving pain coping through enhanced attentional control and acceptance.
- →PracticesGardening TherapyCertaintyLowSourceTheoretical
Gardening therapy is proposed to help with chronic pain through distraction, physical activity and improved mood.
Open Gardening TherapyStudy result
Gardening therapy reduces chronic pain through distraction, physical activity, and improved mood.
- →PracticesGratitude JournalCertaintyLowSourceTheoretical
Gratitude journaling may improve pain coping and reduce pain catastrophizing, though its effects on pain intensity are modest.
Open Gratitude JournalStudy result
Gratitude journaling may improve pain coping and reduce pain catastrophizing, though effects on pain intensity are modest.
- →PracticesHot BathCertaintyLowSourceTheoretical
Hot baths are described as a non-pharmacological approach to managing discomfort associated with chronic low back pain, osteoarthritis, and fibromyalgia.
Open Hot BathStudy result
Hot baths are a non-pharmacological intervention for managing chronic low back pain, osteoarthritis, and fibromyalgia-related discomfort.
- →PracticesPsychotherapyCertaintyLowSourceTheoretical
Cognitive behavioral therapy may improve pain coping and function in chronic pain, independently of changes in nociception.
Open PsychotherapyStudy result
Cognitive-behavioral therapy improves pain coping and function in chronic pain, independent of nociceptive changes.
- →PracticesStrength TrainingCertaintyLowSourceTheoretical
Supervised resistance training modestly reduces pain and improves function in chronic musculoskeletal pain; effects are small to moderate and vary by condition.
Open Strength TrainingStudy result
Supervised resistance training modestly reduces pain and improves function in chronic musculoskeletal pain. Effect sizes are small to moderate and vary by condition.
- →PracticesYin YogaCertaintyLowSourceTheoretical
Yin Yoga’s gentle, sustained stretching and mindfulness may help manage chronic pain by reducing central sensitization and improving fascial mobility, though robust evidence is lacking.
Open Yin YogaStudy result
Yin yoga's gentle, sustained stretching and mindfulness component may help manage chronic pain conditions by reducing central sensitization and improving fascial mobility, though robust evidence is lacking.
Very low probability(1)
- →PracticesBinaural BeatsCertaintyVery lowSourceRCT
A 2024 systematic review of randomized trials found no effect on chronic pain, and the studies did not support this use.
Open Binaural BeatsWho was studied
- People with a condition
What to avoid
Interventions recorded as making it worseNothing in this library is currently recorded as making Chronic Pain worse. Coverage is partial, and absence here is not evidence of safety.
How to read the evidence
Evidence tier — overall strength of the evidence for the whole compound
- StrongWell established — backed by strong, consistent human research.
- ModerateSome genuine support, but mostly from small or lower-quality studies. Promising, not proven.
- PreliminaryEarly-stage evidence — a promising hypothesis, not an established effect yet.
- LimitedVery limited evidence — treat this as a hypothesis, not proof.
- InsufficientNot enough good evidence to draw conclusions yet.
Certainty — how sure we can be that the effect is real
- Very highVery sure — strong, consistent evidence
- HighFairly sure — consistent evidence from good studies
- MediumModerately sure — new studies could change this
- LowNot sure — little or mixed evidence
- Very lowVery unsure — almost no usable evidence
Source — where the data comes from
- Meta-analysisPooled analysis of many trials — the strongest evidence
- RCTRandomized controlled trial — a strong human study design
- ClinicalA human clinical study
- Reference knowledgeFrom general health-science or pharmacology references, not a study of this exact claim
- Animal researchStudied in animals, not humans
- Community reportsAggregated user reports — anecdotal signal, not evidence
- TheoreticalMechanism-based reasoning, not yet tested
Study grade — quality of each underlying study (A best, D weakest)
- AHigh-quality — strong, consistent human trials
- BGood — solid evidence with some limitations
- CModerate — limited, small, or mixed-quality studies
- DWeak — preliminary, indirect, or animal-only
Confidence — how strongly the sources back a finding
A 0–100 score from study quality and agreement
Most supplement evidence is graded C–D. Read it as preliminary signal, not proof.
Full write-up
What is it
Chronic Pain is a health topic within the pain category. The outcome discussed is chronic pain intensity, meaning how strong the pain feels. It provides a focused starting point for understanding pain-related concerns; specific causes, patterns, and treatment considerations may differ between people.
Evidence-backed options
The options associated with Chronic Pain are not interchangeable. They include supplements, mind-body practices, and sauna-based approaches, with evidence ranging from randomized controlled trials and clinical findings to reviews, pharmacology references, and animal research. Omega-3 has the clearest supportive finding among the options described, while evidence for the other approaches is generally more limited or applies to narrower situations.
The populations and pain contexts studied differ. Some findings concern chronic pain broadly, while others relate to musculoskeletal conditions, postoperative spinal pain, or pain associated with a herniated disc. Quercetin is supported only by animal research, so its findings do not directly establish effects in people. CBD remains incompletely established despite promising outcomes in many studies. Yoga findings are also qualified by substantial variation between studies, which limits certainty about the overall result.
No single dose, treatment duration, or time to onset is established across these options in the available summaries. The findings therefore describe different interventions and contexts rather than one standardized approach to Chronic Pain. A clinician can help interpret whether evidence from a particular pain condition or study population is relevant to an individual situation.