Cyclosporine
Use this reference to explore questions about taking other products with Cyclosporine (Neoral). It can help support informed conversations with a healthcare professional.
1 supplements in this library have a recorded interaction with this medication
Weakens or is weakened by
Supplements that may blunt it, or be blunted by it1 listedHighest probability
- →SupplementsChagaCompetitive
Theoretical concern that Chaga's immunostimulant effects may reduce cyclosporine efficacy; clinically significant interaction is not established.
- Trade names
- Cyclosporine (Neoral)
- family
- immunosuppressants
Full write-up
What is it
Cyclosporine (Neoral) is an immune drug in the immunosuppressants family. It is generally used to suppress or reduce immune activity.
This page is an educational reference for considering how other products, including supplements, may interact with Cyclosporine (Neoral). For questions related to a medical condition or treatment, consult a healthcare professional.
What interacts with it
The most important concerns involve changes in cyclosporine exposure or kidney-related risk. Berberine, CBD (Cannabidiol), and Quercetin may inhibit CYP3A4 or P-glycoprotein and increase cyclosporine levels, raising the risk of nephrotoxicity, neurotoxicity, hypertension, or excessive immunosuppression. Echinacea and St. John's Wort may increase metabolism and reduce cyclosporine’s immunosuppressive effect, which can increase the risk of transplant rejection. Potassium may contribute to severe hyperkalemia because cyclosporine can reduce renal potassium excretion, while Psyllium Husk can reduce cyclosporine absorption.
Several other combinations are based on theoretical, product-specific, preclinical, or otherwise limited evidence. Astragalus, Chamomile, Cordyceps, Curcumin, Oregano Oil, Reishi, Resveratrol, Turkey Tail, Vitamin E, and Horny Goat Weed (Epimedium) may affect CYP3A4, P-glycoprotein, or cyclosporine exposure. Chlorella, Holy Basil (Tulsi), and Turkey Tail may also counteract immunosuppression through immune-modulating effects. Aloe Vera, Black Seed Oil, Milk Thistle (Silymarin), and Chaga have limited or unestablished clinical evidence, but cyclosporine’s narrow therapeutic index makes unconfirmed interactions relevant.
Creatine may raise serum creatinine independently of kidney damage, complicating interpretation of renal monitoring. If any of these products are being considered, a prescriber or pharmacist can help determine whether cyclosporine concentrations, kidney function, potassium, or other monitoring is appropriate. No combinations are identified here as useful additions to cyclosporine treatment.