Rare

G6PD Deficiency

G6PD Deficiency is a rare health condition. Its dedicated overview places it within broader health information and provides context for understanding the condition and related considerations in an educational reference setting.

G6PD Deficiency is a rare condition with a dedicated overview of its place in health information.

3What to avoid

This list shows research findings, not treatments. Nothing here replaces medical care. If you have this condition, talk to a doctor.

May not suit people with this condition

Supplements and practices linked to problems for people with this condition.

Ozone TherapypracticeLikely
A systematic review of randomized and non-randomized human studies lists G6PD Deficiency as a contraindication for Ozone Therapy because oxidative stress may trigger hemolysis and a hemolytic crisis.
Open the Ozone Therapy page
Gardening TherapypracticeUnclear
Fava beans or certain leguminous plants in gardens may trigger a hemolytic crisis in people with G6PD deficiency.
Open the Gardening Therapy page
IV Vitamin DrippracticeUnclear
High-dose IV Vitamin C can generate hydrogen peroxide, which may cause acute hemolytic anemia in people with G6PD Deficiency.
Open the IV Vitamin Drip page

The expert view shows every study, dose protocol and source.

What may help

Interventions recorded as helping with this condition

Nothing in this library is currently recorded as helping with G6PD Deficiency. That means nothing is on file — not that nothing exists. Only 107 of 338 catalogued supplements have a written-up profile so far.

Browse the supplements that are written up

What to avoid

Interventions recorded as making it worse3 listed

Highest probability

PracticesOzone TherapyCertaintyHighSourceClinical
A systematic review of randomized and non-randomized human studies lists G6PD Deficiency as a contraindication for Ozone Therapy because oxidative stress may trigger hemolysis and a hemolytic crisis.
Who was studied
People with a condition
Study result
Contraindication for ozone therapy due to risk of hemolytic crisis.
Rationale
Systemic ozone exposure can increase oxidative stress and precipitate hemolysis in people with glucose-6-phosphate dehydrogenase deficiency; this is a standard contraindication for systemic ozone procedures.
Open Ozone Therapy
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Low probability(2)

PracticesGardening TherapyCertaintyLowSourceReference knowledge
Fava beans or certain leguminous plants in gardens may trigger a hemolytic crisis in people with G6PD deficiency.
Rationale
Exposure to fava beans or certain leguminous plants in gardens may trigger hemolytic crisis in individuals with G6PD deficiency.
Open Gardening Therapy
→
PracticesIV Vitamin DripCertaintyLowSourceReference knowledge
High-dose IV Vitamin C can generate hydrogen peroxide, which may cause acute hemolytic anemia in people with G6PD Deficiency.
Rationale
High-dose IV vitamin C generates hydrogen peroxide, which can cause acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase deficiency.
Open IV Vitamin Drip
→

How to read the evidence

Evidence tier — overall strength of the evidence for the whole compound

StrongWell established — backed by strong, consistent human research.
ModerateSome genuine support, but mostly from small or lower-quality studies. Promising, not proven.
PreliminaryEarly-stage evidence — a promising hypothesis, not an established effect yet.
LimitedVery limited evidence — treat this as a hypothesis, not proof.
InsufficientNot enough good evidence to draw conclusions yet.

Certainty — how sure we can be that the effect is real

Very highVery sure — strong, consistent evidence
HighFairly sure — consistent evidence from good studies
MediumModerately sure — new studies could change this
LowNot sure — little or mixed evidence
Very lowVery unsure — almost no usable evidence

Source — where the data comes from

Meta-analysisPooled analysis of many trials — the strongest evidence
RCTRandomized controlled trial — a strong human study design
ClinicalA human clinical study
Reference knowledgeFrom general health-science or pharmacology references, not a study of this exact claim
Animal researchStudied in animals, not humans
Community reportsAggregated user reports — anecdotal signal, not evidence
TheoreticalMechanism-based reasoning, not yet tested

Study grade — quality of each underlying study (A best, D weakest)

AHigh-quality — strong, consistent human trials
BGood — solid evidence with some limitations
CModerate — limited, small, or mixed-quality studies
DWeak — preliminary, indirect, or animal-only

Confidence — how strongly the sources back a finding

A 0–100 score from study quality and agreement

Most supplement evidence is graded C–D. Read it as preliminary signal, not proof.

Full write-up

What is it

Evidence-backed options

No evidence-backed options are listed for G6PD Deficiency. As a result, there is no basis here for comparing supplements or other options for this condition. Any questions about managing G6PD Deficiency should be discussed with a qualified clinician.

What to avoid

Several items are flagged because they may increase oxidative stress, which can damage red blood cells when G6PD-related redox defenses are impaired. Garlic contains oxidant compounds, while systemic Ozone Therapy can increase oxidative stress directly. Beetroot Extract may expose a person to nitrites, which can also promote oxidative stress. Ginkgo Biloba has been associated with hemolytic anemia in people with G6PD deficiency, and its flavonoid compounds may trigger oxidative stress in red blood cells. High doses of Vitamin K1 may cause hemolysis, while Quercetin carries a theoretical risk because of pro-oxidant effects at high doses.

Vitamin C requires a more specific distinction. Pharmacologic intravenous Vitamin C can generate hydrogen peroxide and cause severe hemolysis when erythrocyte glutathione regeneration is impaired. The concern described here applies to high-dose intravenous treatment, not ordinary dietary intake.

Berberine is flagged through a different pathway. G6PD deficiency can predispose to hemolysis and hyperbilirubinemia, while berberine-related bilirubin displacement may further increase the risk of kernicterus, particularly in infants.

Cigarette Smoking is flagged based on its physiological properties, although a more specific mechanism is not provided here. Because the relevance of these concerns can vary with the substance, form, exposure, and age, people with G6PD Deficiency can discuss any medical treatment or supplement with a clinician.