Drug Addiction

Drug Addiction is a condition listed in the mental health category. The evidence summarized here considers cocaine craving and relapse among people being treated for CUD.

Explore Drug Addiction as a condition listed in the mental health category.

3What may help

This list shows research findings, not treatments. Nothing here replaces medical care. If you have this condition, talk to a doctor.

What may help

What studies found for each option, best evidence first.

3 options:3 some evidence

What studies foundSize of effect

CardiopracticeSome evidence it helpsSize of effect: Not known
Some human studies found a benefit. More research could change this.
All 2 studies with a clear result found a benefit.
Open the Cardio page
QigongpracticeSome evidence it helpsSize of effect: Not known
Some human studies found a benefit. More research could change this.
All 2 studies with a clear result found a benefit.
A meta-analysis combining randomized and non-randomized human studies found reduced anxiety and depression compared with no treatment or medication, but not compared with TAU. Another meta-analysis reported improvements in depression, anxiety, quality of life, and sleep quality among people with drug addiction.
Open the Qigong page
YogapracticeSome evidence it helpsSize of effect: Not known
Some human studies found a benefit. More research could change this.
All 2 studies with a clear result found a benefit.
Open the Yoga page

The expert view shows every study, dose protocol and source.

What may help

Interventions recorded as helping with this condition3 listed

Most likely to help, from the evidence we have

PracticesCardioCertaintyMediumSourceRCT
A pooled analysis whose designs were not recorded found reduced drug craving with aerobic exercise (SMD -0.73), HIIT (SMD -2.19), and aerobic+resistance exercise (SMD -1.96). A separate RCT in 58 methadone-treated men reported changes in GPX4, SLC7A11, and ferritin with aerobic exercise, alone or with an NBS supplement.
Who was studied
People with a condition
Study result
Network meta-analysis of 30 RCTs showing aerobic exercise, HIIT, and aerobic+resistance exercise significantly reduce drug craving versus control (SMD -0.73, -2.19, -1.96 respectively)
Open Cardio
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PracticesQigongCertaintyMediumSourceClinical
A meta-analysis combining randomized and non-randomized human studies found reduced anxiety and depression compared with no treatment or medication, but not compared with TAU. Another meta-analysis reported improvements in depression, anxiety, quality of life, and sleep quality among people with drug addiction.
Who was studied
People with a condition
Addiction
Addiction Drugs
Study result
Meta-analysis of 7 studies (1 RCT, 6 NRS) showing Qigong exercise significantly reduced anxiety and depression compared to no treatment or medication, though not superior to TAU.
Open Qigong
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PracticesYogaCertaintyMediumSourceClinical
In a randomized controlled trial of 59 men with OUD, yoga added to buprenorphine was associated with faster withdrawal stabilization than usual treatment (HR 4.40; median 5 vs 9 days), alongside improvements in HRV measures, anxiety, sleep latency, and pain. A separate trial enrolled 60 people in drug-addiction rehabilitation and proposed yoga as an adjunctive therapy.
Who was studied
People with a condition
Addiction
Addiction Drugs
Study result
RCT of 59 male patients with OUD; yoga add-on to buprenorphine accelerated withdrawal stabilization (HR 4.40; median 5 vs 9 days) and improved HRV (LF/HF, LF, HF power), anxiety (HAM-A), sleep latency, and pain versus treatment as usual
Open Yoga
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What to avoid

Interventions recorded as making it worse

Nothing in this library is currently recorded as making Drug Addiction worse. Coverage is partial, and absence here is not evidence of safety.

Browse the supplements that are written up

How to read the evidence

Evidence tier — overall strength of the evidence for the whole compound

StrongWell established — backed by strong, consistent human research.
ModerateSome genuine support, but mostly from small or lower-quality studies. Promising, not proven.
PreliminaryEarly-stage evidence — a promising hypothesis, not an established effect yet.
LimitedVery limited evidence — treat this as a hypothesis, not proof.
InsufficientNot enough good evidence to draw conclusions yet.

Certainty — how sure we can be that the effect is real

Very highVery sure — strong, consistent evidence
HighFairly sure — consistent evidence from good studies
MediumModerately sure — new studies could change this
LowNot sure — little or mixed evidence
Very lowVery unsure — almost no usable evidence

Source — where the data comes from

Meta-analysisPooled analysis of many trials — the strongest evidence
RCTRandomized controlled trial — a strong human study design
ClinicalA human clinical study
Reference knowledgeFrom general health-science or pharmacology references, not a study of this exact claim
Animal researchStudied in animals, not humans
Community reportsAggregated user reports — anecdotal signal, not evidence
TheoreticalMechanism-based reasoning, not yet tested

Study grade — quality of each underlying study (A best, D weakest)

AHigh-quality — strong, consistent human trials
BGood — solid evidence with some limitations
CModerate — limited, small, or mixed-quality studies
DWeak — preliminary, indirect, or animal-only

Confidence — how strongly the sources back a finding

A 0–100 score from study quality and agreement

Most supplement evidence is graded C–D. Read it as preliminary signal, not proof.

Full write-up

What is it

Drug Addiction is a condition listed in the mental health category. The evidence summarized here considers cocaine craving and relapse among people being treated for CUD. CBD (Cannabidiol) did not reduce either outcome in that setting.

Evidence-backed options

CBD (Cannabidiol) has been investigated in relation to cocaine use disorder, but it did not reduce cocaine craving or relapse among people being treated for CUD. This finding does not support describing CBD as an effective option for these outcomes.

No dose, treatment duration, or timing of effects is specified, so it is not possible to say what was taken, for how long, or how quickly any effect might appear. The health status of the people studied was not specified, which limits how broadly the finding can be applied. Any medical condition should be discussed with a clinician.