Antihypertensives: Interaction Information

Interactions

Supplement interactions on file

No supplement in this library is recorded as interacting with this medication. Coverage is partial — 171 of 216 medications have interaction data, drawn from the 107 supplements written up so far. Absence here is incomplete coverage, not a safety claim.

Browse the supplements that are written up

Trade names: Lisinopril, Amlodipine, Losartan, Metoprolol, Hydrochlorothiazide, Hydralazine
family: antihypertensives

Full write-up

What is it

Antihypertensives are cardiovascular medicines in the antihypertensive family, generally used to manage high blood pressure. Examples include Lisinopril, Amlodipine, Losartan, Metoprolol, Hydrochlorothiazide, and Hydralazine.

This page is an educational reference for considering how other supplements or medicines, such as Citrulline or Coenzyme Q10, may interact with antihypertensives. Consult a clinician about any medical condition or treatment decision.

What interacts with it

The main concern is additive blood-pressure lowering. Alpha-Lipoic Acid (ALA), Ashwagandha, Astaxanthin, Astragalus, Black Seed Oil, Citrulline, Coenzyme Q10, Cordyceps, Flaxseed Oil, Holy Basil (Tulsi), Krill Oil, Lemon Balm (Melissa), Lycopene, Oregano Oil, Quercetin, Resveratrol, Saffron Extract, Shilajit, and Tribulus Terrestris may add to the effects of antihypertensive medications. Depending on the combination, this may lead to unusually low blood pressure, dizziness, weakness, fainting, or falls. The possibility may be more relevant when multiple antihypertensive agents are used. Choline (Bitartrate), Horny Goat Weed (Epimedium), and L-Theanine may also contribute to this additive effect.

Some interactions are less certain. A blood-pressure-lowering interaction with Maca Root has not been established, and the possible interaction with Reishi is theoretical because human evidence does not establish a clinically meaningful blood-pressure effect. Rhodiola Rosea has uncertain effects that may depend on its formulation, so an additive effect cannot be excluded. These combinations are better treated as situations for monitoring and discussion with a prescriber or pharmacist rather than as established effects.

L-Theanine is a special case: it may complement antihypertensive therapy through stress-mediated blood-pressure reduction, but that potential benefit also creates a risk of excessive blood-pressure lowering. Its combination with antihypertensive medications requires strict medical supervision. Anyone considering one of these supplements alongside antihypertensive treatment should discuss the combination with a clinician, especially if dizziness, fainting, or unexpectedly low blood pressure occurs.