Amiodarone
Considering Amiodarone (Cordarone, Pacerone) with another medicine or supplement? Use this reference to review potential combinations.
1 supplements in this library have a recorded interaction with this medication
Dangerous combinations
Supplements recorded as risky with this medication1 listedHighest severity first
- →SupplementsSea Moss (Irish Moss)TheoreticalCaution
Amiodarone already supplies a large iodine burden, so additional variable iodine from sea moss may increase the risk of iodine-induced hypothyroidism or hyperthyroidism.
Where the evidence comes from
- Reference knowledge
Open Sea Moss (Irish Moss)Confidence
confidence 75/100
- Trade names
- Amiodarone (Cordarone, Pacerone)
Full write-up
What is it
Amiodarone (Cordarone, Pacerone) is a cardiovascular medicine. This page provides educational reference information for reviewing potential combinations with other medicines or supplements. It is not medical advice; consult a clinician regarding any medical condition or questions about treatments and combinations.
What interacts with it
The most serious concerns involve Iodine and Vitamin B6 (Pyridoxine). Amiodarone already contains a high iodine content, so additional Iodine may precipitate or worsen amiodarone-induced thyrotoxicosis. Sea Moss (Irish Moss) can also add a variable iodine burden, potentially increasing the risk of iodine-induced hypothyroidism or hyperthyroidism. Vitamin B6 (Pyridoxine) may amplify amiodarone-associated photosensitivity, raising the possibility of severe sunburn, blistering, or a phototoxic rash.
Several supplements may add to amiodarone’s effects on heart rhythm or its handling in the body. Berberine can inhibit cardiac potassium channels and slow heart rate, which may increase QT prolongation, bradycardia, and proarrhythmic risk when combined with amiodarone. CBD (Cannabidiol) can affect amiodarone metabolism through CYP3A4 and CYP2C9 inhibition and may add to QT prolongation and bradycardia risk. Quercetin may inhibit CYP3A4, potentially increasing amiodarone levels and the risk of QT prolongation and arrhythmias.
For Black Seed Oil, the concern is theoretical and relates to a possible CYP3A4 interaction; clinical evidence that it increases amiodarone toxicity is lacking. Because these interactions involve thyroid function, sun sensitivity, heart rate, or rhythm, people considering any of these supplements should discuss the combination with a prescriber or pharmacist.