ACE Inhibitors

ACE Inhibitors are cardiovascular medicines in the antihypertensives family, generally used to manage high blood pressure. This group includes Enalapril, Lisinopril, Captopril, Ramipril, Perindopril, and Benazepril.

This page is an educational reference for considering possible interactions with other products, including Sodium Bicarbonate, Sea Moss (Irish Moss), Beetroot Extract, Potassium, and Iodine. Anyone with a medical condition should consult a clinician about their individual medicines and products.

The main concern across these interactions is potassium balance. ACE inhibitors reduce aldosterone secretion, which decreases renal potassium excretion. Adding Potassium can therefore cause potassium to accumulate, potentially leading to life-threatening hyperkalemia with cardiac arrhythmias.

Several other supplements may add to this risk through their potassium content or effects on potassium handling. Beetroot Extract and Sea Moss (Irish Moss) may increase potassium exposure when combined with ACE inhibitors. High-dose potassium iodide or concentrated Iodine preparations may also contribute to hyperkalemia, with greater concern in people with renal impairment or those using other potassium-retaining therapies.

Sodium Bicarbonate presents a different potassium-related concern. It can alter potassium balance, and bicarbonate-induced alkalosis drives potassium into cells. This may produce unpredictable potassium shifts and potentially mask the risk of hyperkalemia associated with ACE inhibitors.

These combinations warrant review with a prescriber or pharmacist, especially when kidney function is impaired, another potassium-retaining therapy is used, or a concentrated supplement preparation is involved. No combination in this group is identified as a useful pairing with ACE inhibitors.