Hyperuricemia (High Uric Acid)
Hyperuricemia, also called high uric acid, is a metabolic condition in which the concentration of uric acid in the blood is elevated. It describes a biochemical finding rather than a specific intervention or supplement effect, and the information here does not establish that every person will notice symptoms.
Hyperuricemia—also called high uric acid—is classified as a metabolic condition.
This list shows research findings, not treatments. Nothing here replaces medical care. If you have this condition, talk to a doctor.
May not suit people with this condition
Supplements and practices linked to problems for people with this condition.
FastingpracticePossible
The expert view shows every study, dose protocol and source.
What may help
Interventions recorded as helping with this conditionNothing in this library is currently recorded as helping with Hyperuricemia (High Uric Acid). That means nothing is on file — not that nothing exists. Only 107 of 338 catalogued supplements have a written-up profile so far.
What to avoid
Interventions recorded as making it worse1 listedHighest probability
- →PracticesFastingCertaintyMediumSourceClinical
A randomized trial in 64 healthy participants excluded people with diagnosed hyperuricemia and found uric acid rose by +140.15 ± 11.79 µmol/L during the studied protocol (p < 0.001). The authors said safety could not be anticipated for people susceptible to gout attacks.
Who was studied
- Healthy people
Study result
Diagnosed hyperuricemia was an explicit exclusion criterion; uric acid rose by +140.15 ± 11.79 µmol/L during the MFP (p < 0.001); authors state 'safety of MFP cannot be anticipated in individuals susceptible to gout attacks'.
Open FastingRationale
Diagnosed hyperuricemia was an explicit exclusion criterion; uric acid rose by +140.15 ± 11.79 µmol/L during the MFP (p < 0.001); authors state 'safety of MFP cannot be anticipated in individuals susceptible to gout attacks'.
How to read the evidence
Evidence tier — overall strength of the evidence for the whole compound
- StrongWell established — backed by strong, consistent human research.
- ModerateSome genuine support, but mostly from small or lower-quality studies. Promising, not proven.
- PreliminaryEarly-stage evidence — a promising hypothesis, not an established effect yet.
- LimitedVery limited evidence — treat this as a hypothesis, not proof.
- InsufficientNot enough good evidence to draw conclusions yet.
Certainty — how sure we can be that the effect is real
- Very highVery sure — strong, consistent evidence
- HighFairly sure — consistent evidence from good studies
- MediumModerately sure — new studies could change this
- LowNot sure — little or mixed evidence
- Very lowVery unsure — almost no usable evidence
Source — where the data comes from
- Meta-analysisPooled analysis of many trials — the strongest evidence
- RCTRandomized controlled trial — a strong human study design
- ClinicalA human clinical study
- Reference knowledgeFrom general health-science or pharmacology references, not a study of this exact claim
- Animal researchStudied in animals, not humans
- Community reportsAggregated user reports — anecdotal signal, not evidence
- TheoreticalMechanism-based reasoning, not yet tested
Study grade — quality of each underlying study (A best, D weakest)
- AHigh-quality — strong, consistent human trials
- BGood — solid evidence with some limitations
- CModerate — limited, small, or mixed-quality studies
- DWeak — preliminary, indirect, or animal-only
Confidence — how strongly the sources back a finding
A 0–100 score from study quality and agreement
Most supplement evidence is graded C–D. Read it as preliminary signal, not proof.
Full write-up
What is it
Hyperuricemia, also called high uric acid, is a metabolic condition in which the concentration of uric acid in the blood is elevated. It describes a biochemical finding rather than a specific intervention or supplement effect, and the information here does not establish that every person will notice symptoms.
Research has examined options including Quercetin, Resveratrol, Vitamin C, and Vitamin B6 (Pyridoxine), but the populations and study settings differ. For example, Quercetin was studied in animal models, while Resveratrol was studied in subjects with dyslipidemia.
Evidence-backed options
The options associated with Hyperuricemia (High Uric Acid) have different levels and types of support, and the findings should not be interpreted as equivalent. Quercetin has been examined in animal models, so its findings may not apply directly to people. Resveratrol and Vitamin C have been studied in people, but the reported findings are limited to specific contexts rather than establishing a general effect for everyone with high uric acid.
For Resveratrol, the reported amounts were 300 mg/d and 600 mg/d in subjects with dyslipidemia. The available finding concerns serum uric acid concentration; it does not establish how quickly a change might appear or how long any change might last. Vitamin C was reported to decrease serum uric acid levels without affecting uric acid excretion, which leaves the broader clinical significance uncertain.
Vitamin B6 (Pyridoxine) has not shown an association between higher intake and risk of Hyperuricemia (High Uric Acid) in males and females. This type of finding does not establish that supplementation treats high uric acid. Across these options, no duration or onset information is provided, and the evidence remains limited, particularly for applying the findings to people with different health conditions. Anyone considering these options for a medical condition should discuss them with a clinician.